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CDC announces interim Zika guidance

A clinical lab analyst warms a frozen reagent known as a “normal control” before it is used in the Zika testing process.
A clinical lab analyst warms a frozen reagent known as a “normal control” before it is used in the Zika testing process.
July 27, 2017 -- The CDC announced on July 26 updated interim guidance for U.S. health care providers caring for pregnant women with possible Zika virus exposure. The interim guidance was issued because of declining prevalence of Zika virus disease in the Americas and emerging evidence indicating prolonged detection of Zika virus immunoglobulin M (IgM) antibodies.

Accurate diagnosis of Zika virus infection can be challenging because the virus is present in body fluids only for a brief time, and serologic testing cannot always reliably determine when an infection occurred. With the declining prevalence of Zika virus disease and a high level of serological cross-reactivity with other flaviviruses (viruses transmitted primarily by ticks and mosquitos), the probability of false-positive test results increases.

The updated guidance emphasizes a shared decision-making model for testing and screening pregnant women, in which patients and providers work together to make decisions about testing and care plans based on patient preferences and values, clinical judgment, and a balanced assessment of risks and expected outcomes.

CDC continues to recommend Zika virus testing for all symptomatic persons (including those who are pregnant and those who are not) with possible Zika virus exposure through travel or sex.

CDC is no longer routinely recommending Zika virus testing for asymptomatic pregnant women with possible Zika virus exposure through travel or sex. Instead, the agency is recommending that patients and their health care providers work together to make decisions about testing and care plans based on patient preferences and values, clinical judgment, and a balanced assessment of risks and expected outcomes.

Health care providers in Iowa suspecting a potential case of Zika virus should first contact the Iowa Department of Public Health’s Center for Acute Disease Epidemiology at 800-362-2736. CADE staff will consult with the provider to determine whether the case meets the CDC testing criteria. If testing is warranted, CADE staff will determine the specimens to collect, provide appropriate test request forms, and make arrangements for courier pick-up and delivery of specimens to the State Hygienic Laboratory.

Updated guidance can be found on the CDC Zika website.